Actin cytoskeleton in angiogenesis
*Biology Open* (2022) 11 (12): bio058899. Detailed exploration of the actin cytoskeletal remodeling that orchestrates endothelial cell migration and vessel sprouting.
PhD Research Scholar @ inStem, Bengaluru
Exploring the
Biology of Muscle.
I am a biologist studying the macromolecular machinery of skeletal muscle, cytoskeletal dynamics during muscle development, and the structural foundations of genetic muscle disorders.
PhD Scholar @ inStem, India
Background
About Me & Academic Journey
From applied sericulture to the biophysics of skeletal muscle architecture.
I am an applied entomologist turned biologist. My academic journey commenced with an undergraduate degree in Sericulture, followed by a postgraduate specialization in Biotechnology.
Fascinated by macromolecular self-assembly and cellular architecture, I transitioned into muscle biology. I am currently pursuing doctoral research at inStem, Bengaluru, studying fundamental cytoskeletal dynamics during muscle cell development.
Beyond the wet lab, I am passionate about computational biology, data visualization, scientific communication (SciComm), and sharing biological science through platforms like Silkpedia.
Education & Training
2022 – 2027 (Expected)
Ph.D. Research Scholar (Biotechnology)
DBT-inStem, Bengaluru & Regional Centre for Biotechnology (RCB)
Investigating muscle biology, cytoskeletal dynamics, and myogenesis.
2020 – 2022
Master of Science (M.Sc. Biotechnology)
DBT-Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram & RCB
Specialized in cell biology, biochemistry, and structural biochemistry.
2015 – 2019
Bachelor of Science (B.Sc. Sericulture)
Forest College and Research Institute (FCRI), Mettupalayam (TNAU)
Applied entomology, silkworm genetics, silk protein biochemistry, and pathology.
Research Scope
Broad Research Interests in Muscle Biology
Investigating the fundamental principles of muscle architecture, cytoskeletal organization, and cellular physiology.
Skeletal Muscle Myogenesis
Studying myoblast differentiation, cell fusion, and the coordinated temporal assembly of structural complexes during muscle formation.
Cytoskeletal Architecture
Understanding the macromolecular organization of striated muscle units, thin filament networks, and anchoring multiprotein complexes.
Genetic Muscle Pathologies
Exploring how genetic variations in structural muscle genes disrupt mechanical integrity and lead to congenital muscle weaknesses.
Bio-Imaging & Computation
Utilizing high-resolution fluorescence confocal imaging, structural alignment algorithms, and quantitative morphometric analysis.
Scholarly Work
Peer-Reviewed Publications
Review articles and book chapters documenting cellular dynamics, cytoskeletal regulation, and receptor trafficking.
Integrin receptor trafficking in health and disease
*Progress in Molecular Biology and Translational Science*, Vol 191, Academic Press (2022). Comprehensive analysis of endocytic recycling and signal transduction pathways mediated by integrins.
Computation & Tooling
Computational Biology & Workflows
Bridging wet-lab biology with reproducible data processing, image analysis, and scripting.
REPRODUCIBLE RESEARCH
Bioinformatics & Laboratory Automation
Writing reproducible analysis pipelines in Python and Fiji macro languages to parse sequence databases, automate confocal microscopy segmentation, and manage versioned research data.
Python & Biopython
Genomic sequence analysis, structural alignment algorithms, and quantitative morphometrics.
Microscopy Automation
Custom ImageJ / Fiji macro scripts for batch multi-channel confocal stack thresholding and measurement.
Reproducible Science
Open-source version control with Git and GitHub, adhering to transparent and reproducible research standards.
Writing & Illustration
Science Communication & Outreach
Translating biological discovery into engaging narratives, educational articles, and digital scientific illustration.
POPULAR SCIENCE & BLOG
🦋 Silkpedia — The World of Sericulture & Silk Biology
Founded by Victor Samuel I, Silkpedia is an educational initiative dedicated to the science of silkworms, host plant cultivation, silk protein biochemistry (fibroin and sericin), and sustainable sericulture traditions connected with modern molecular biology.
🎨 Scientific Illustrations
Integrin Receptor Trafficking & Recycling
Vector pathway schematic detailing clathrin-dependent endocytosis, early sorting endosomes, and Rab4/Rab11 polarized recycling loops back to leading edge lamellipodia.
Actin Dynamics during Angiogenic Sprouting
Biological illustration depicting endothelial tip cell filopodia protrusion, F-actin filament bundling, lamellipodial Arp2/3 meshworks, and focal adhesion anchoring along VEGF gradients.
Sarcomere Macromolecular Architecture
Schematic of striated muscle contractile units illustrating Z-disc boundaries, thin actin and thick myosin filament interdigitation, titin elastic anchoring, and A-band spacing.
Silk Fibroin Nano-Architecture
Structural diagram of antiparallel beta-sheet crystalline domains in silkworm (Bombyx mori) fibroin, showcasing hydrogen-bonded motifs that produce high tensile modulus.
Get in Touch
Let's Connect & Collaborate
Whether you are interested in muscle biology discussions, academic collaboration, or science communication, feel free to reach out.